DI-T-BUTYL MALONATE
Di-tert-butyl malonate
CAS: 541-16-2
Molecular Formula: C11H20O4
DI-T-BUTYL MALONATE - Names and Identifiers
| Name | Di-tert-butyl malonate |
| Synonyms | DI-T-BUTYL MALONATE Di-tert-Butyl malote DI-TERT-BUTYL MALONATE Di-tert-butyl malonate di-tert-butyl propanedioate 1,3-di-tert-butyl propanedioate bis(1,1-dimethylethyl) malonate MALONIC ACID DI-TERT-BUTYL ESTER propanedioicacid,bis(1,1-dimethylethyl)ester Propanedioic acid, bis(1,1-dimethylethyl) ester Di-tert-butyl malonate stab. with potassium carbonate |
| CAS | 541-16-2 |
| EINECS | 208-769-6 |
| InChI | InChI=1/C11H20O4/c1-10(2,3)14-8(12)7-9(13)15-11(4,5)6/h7H2,1-6H3 |
| InChIKey | CLPHAYNBNTVRDI-UHFFFAOYSA-N |
DI-T-BUTYL MALONATE - Physico-chemical Properties
| Molecular Formula | C11H20O4 |
| Molar Mass | 216.27 |
| Density | 0.966 g/mL at 25 °C (lit.) |
| Melting Point | -7--6 °C (lit.) |
| Boling Point | 110-111 °C/22 mmHg (lit.) |
| Flash Point | 88 °C |
| Water Solubility | It is hardly soluble in water. |
| Solubility | Chloroform, Ethyl Acetate |
| Vapor Presure | 0.132mmHg at 25°C |
| Appearance | Liquid |
| Color | Clear colorless to slightly yellow |
| Merck | 14,3034 |
| BRN | 1781766 |
| pKa | 11.87±0.46(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | n20/D 1.418(lit.) |
DI-T-BUTYL MALONATE - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R24/25 - |
| Safety Description | S23 - Do not breathe vapour. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29171910 |
DI-T-BUTYL MALONATE - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Application | Ditert-butyl malonate is a diester of malonate. The hydrogen atom on the active methylene group in the malonate diester molecule is easy to react with other groups, so it can carry out alkylation, hydroxylation, amidation and other reactions. It is an important intermediate for the synthesis of medicine, pesticide, dye, perfume and other fine chemicals. |
| Preparation | Step 1, malonic acid dichloride: First, 8.0g(76.9 mmol) of malonic acid and 30.0g(0.25 mol) of thionyl chloride are heated at 50°C for 3 days, and then at 60°C for 6 hours. After removing thionyl chloride in a rotary vaporizer, distill the residue. Output: 6.3g(58%), oil, boiling point 43 ℃/ 12 Torr. Step 2: ditert-butyl malonate: at room temperature, drop 19.5g(0.26 mol) of anhydrous tert-butanol in 20 mL of anhydrous N,N-dimethylaniline solution with 6.0 g(0.43 mmol) of anhydrous CHCl3 solution. Subsequently, the solution was heated under reflux for 4 hours, and 40mL 3M sulfuric acid was added to the cooled solution. The aqueous phase was extracted 3 times with 50mL ether. The combined organic phase was washed with 20 mL of water, 20 mL of saturated potassium carbonate solution and 20 mL of saturated sodium chloride solution. The ether phase is dried and filtered by magnesium sulfate. After evaporating the solvent, the residue is distilled. Output: 6.0g(62%),bp 93 ℃/ 10Torr. |
Last Update：2024-04-09 02:00:05
Supplier List
Featured ProductsSpot supply
Product Name: Di-tert-butyl malonate Visit Supplier Webpage Request for quotationCAS: 541-16-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Di-tert-butyl malonate Request for quotationCAS: 541-16-2
Tel: +86-17505207175
Email: 3787852685@qq.com
Mobile: +86-17505207175
QQ: 3787852685
Wechat: chemical6666
Spot supply
Product Name: Di-tert-butyl malonate Request for quotationCAS: 541-16-2
Tel: +86-13776910623
Email: r@reformchem.com
Mobile: +86-13776910623
QQ: 3785839865
Wechat: chemical6666
Spot supply
Product Name: Di-tert-Butyl malonate Request for quotationCAS: 541-16-2
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Di-tert-butyl malonate Visit Supplier Webpage Request for quotationCAS: 541-16-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Di-tert-butyl malonate Visit Supplier Webpage Request for quotationCAS: 541-16-2
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Featured ProductsSpot supply
Product Name: Di-tert-butyl malonate Visit Supplier Webpage Request for quotationCAS: 541-16-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Di-tert-butyl malonate Request for quotationCAS: 541-16-2
Tel: +86-17505207175
Email: 3787852685@qq.com
Mobile: +86-17505207175
QQ: 3787852685
Wechat: chemical6666
Spot supply
Product Name: Di-tert-butyl malonate Request for quotationCAS: 541-16-2
Tel: +86-13776910623
Email: r@reformchem.com
Mobile: +86-13776910623
QQ: 3785839865
Wechat: chemical6666
Spot supply
Product Name: Di-tert-Butyl malonate Request for quotationCAS: 541-16-2
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Di-tert-butyl malonate Visit Supplier Webpage Request for quotationCAS: 541-16-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Di-tert-butyl malonate Visit Supplier Webpage Request for quotationCAS: 541-16-2
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
View History